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Article

Metabolic brain connectivity analysis of a depressive-like phenotype in rats: a graph theory PET study.

Psychiatry research - 1 Apr 2026

Vazquez-Matias Daniel A, de Vries Erik F J, Guerrin Cyprien G J, Prasad Kavya, Doorduin Janine

Abstract excerpt

This study aimed to investigate whether there are metabolic connectivity alterations in the brain of rats with a depressive-like phenotype, using positron emission tomography (PET) and graph theory methods. Male Wistar rats were exposed to 5 days of repeated social defeat (RSD) to induce a depressive-like phenotype, and brain connectivity was assessed with [18F]FDG-PET. Sucrose preference tests were conducted to...

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PMID: 41576488
DOI: 10.1016/j.psychres.2026.116951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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