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Article

Consequences of Hypoxic Events, Necrosis, and Microvascular Density, in Astrocytoma IDH-Mutant, CNS WHO Grade 4.

Medical sciences (Basel, Switzerland) - 23 Dec 2025

Orasanu Cristian Ionut, Bosoteanu Madalina, Vamesu Sorin, Voda Raluca Ioana, Sincu Anamaria, Deacu Mariana

Abstract excerpt

Background/Objectives: Astrocytoma IDH-mutant CNS WHO grade 4 is a malignant tumor of the central nervous system characterized by tumor necrosis, microvascular proliferation, and/or homozygous CDKN2A/B deletion. This study aims to investigate the prognostic role of the consequences of hypoxic events leading to necrosis and microvascular density, observing their associations with clinical-imaging parameters and...

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Source

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Identifiers

PMID: 41562896
DOI: 10.3390/medsci14010006
PMCID: PMC12821448

Genes

CDKN2A
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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