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Article

Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy.

Frontiers in immunology - 1 Jan 2025

Yang Hui-Li, Shi Jia-Wei, Lai Zhen-Zhen, Li Xin, Gu Chun-Jie, Zheng Zi-Meng, Zhao Hong-Bo, Ye Jiang-Feng, Wang Li, Peng Ting, Li Ming-Qing

Abstract excerpt

Introduction: Dramatic alterations of the extracellular matrix (ECM), which can regulate cell behavior by binding to adhesion molecules and are intrinsically linked to immune regulation, occur in decidualization during early pregnancy. Decidual macrophages (dMφ) are a group of tissue-resident cells with an affinity for adhesion. An interactive dialogue occurs between decidual stromal cells (DSCs) and dMφ, however...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41562067
DOI: 10.3389/fimmu.2025.1747323
PMCID: PMC12812556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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