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Genomic insights into antibiotic resistance, virulence traits and phylogenetic lineages of 141 clinical Helicobacter pylori isolates from Eastern China.

Frontiers in cellular and infection microbiology - 1 Jan 2025

Wang Pingping, Zhao Jing, Lv Bin, Zhang Xiaohan, Li Ming, Chen Shenglan, Fan Bingjie, Wang Wenhong

Abstract excerpt

Objective: To characterize antibiotic resistance, virulence genotypes and phylogenetic lineages of Helicobacter pylori (H. pylori) isolates from Eastern China and identify resistance/virulence-associated genetic variants. Methods: Whole-genome sequencing (WGS) and phenotypic antimicrobial susceptibility testing (AST) for 6 antibiotics were performed on 141 H. pylori isolates from Hangzhou, China. Genetic analysis...

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Identifiers

PMID: 41561082
DOI: 10.3389/fcimb.2025.1726881
PMCID: PMC12812873

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