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Article

Global genomic landscape of antimicrobial resistance in Helicobacter pylori: Large-scale analysis of resistance genes, lineages, and evolutionary trajectories.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2026

Alhusseini Laith B, Laftah Ali R, Jaafar Firas Nabeeh, Kouhsari Ebrahim, Beig Masoumeh

Abstract excerpt

BACKGROUND: Antimicrobial resistance (AMR) in Helicobacter pylori is increasingly compromising eradication therapies worldwide. Despite growing concern, comprehensive global genomic analyses integrating resistance determinants, geographic distribution, and evolutionary patterns remain limited. METHODS: A total of 6876 high-quality H. pylori genomes collected from 85 countries between 1900 and 2024 were analyzed....

Read the complete abstract on PubMed

Topics

Helicobacter pylori
Anti-Bacterial Agents
Genome, Bacterial
Drug Resistance, Bacterial
Helicobacter Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Evolution, Molecular

Humans

Genomics

Phylogeny

Mutation

Source

Identifiers

PMID: 42492828
DOI: 10.1016/j.meegid.2026.105990

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