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Article

PRC2-Related Epigenetic Age Acceleration in Acute Myeloid Leukemia with DNMT3A and IDH2 Mutations.

Advanced biology - 1 Jan 2026

Yan Zhengyi, Yuan Luowei, Wang Jinxing, Gu Shen, Lei Yong

Abstract excerpt

Aging is closely linked to epigenetic remodeling, with DNA methylation (DNAm) emerging as a robust biomarker for estimating epigenetic age (EA) and quantifying senescence. Dysregulation of aging-associated DNAm has been implicated in diverse pathologies, including acute myeloid leukemia (AML). However, the effect of these epigenetic alterations in diseases and the underlying mechanism remains largely...

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Share to Aging
Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Epigenesis, Genetic

Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

Share to Polycomb Repressive Complex 2

Source

Open in PubMed Open full text

Identifiers

PMID: 41556261
DOI: 10.1002/adbi.202500710
PMCID: PMC12817234

Genes

DNMT3A
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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