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Article

Family History of Kidney Failure, APOL1 Risk Variants, Social Determinants of Health, and Risk of CKD Progression: Findings From the CRIC Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Apr 2026

Lin Wei, Chang Alexander R, Crews Deidra C, Purnell Tanjala S, Appel Lawrence J, Ishigami Junichi

Abstract excerpt

RATIONALE & OBJECTIVE: Kidney disease is often clustered within families, including Black families, which could be due in part to shared adverse social determinants of health (SDoHs) and/or genetic factors. We hypothesize that the association between family history of kidney failure and chronic kidney disease (CKD) progression is largely attenuated when adjusting for adverse SDoHs and apolipoprotein L1 (APOL1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41547465
DOI: 10.1053/j.ajkd.2025.11.008
PMCID: PMC13180344

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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