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Article

Analysis of tumor stem cell recruitment and integration in microvascular architectural heterogeneity during oral mucosal carcinogenesis: an in vivo experimental study.

Journal of translational medicine - 16 Jan 2026

Liu Xuqian, Chen Xiao, Wang Jie, He Lingxiao, Yin Shigang, Chen Li, Tang Yong, Zheng Xiaoli, Nie Minhai

Abstract excerpt

BACKGROUND: Tumor stem cells (TSCs) play a central role in oral mucosal carcinogenesis by promoting tumor growth, invasion, and angiogenesis. Microvascular architectural phenotype heterogeneity (MAPH) and vasculogenic mimicry (VM) contribute to vascular complexity within tumors and resistance to conventional anti-angiogenic therapies. However, the mechanisms through which TSCs influence MAPH and VM formation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41546115
DOI: 10.1186/s12967-026-07704-2
PMCID: PMC12896178

Genes

ANGPTL2
EEF1E1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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