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Article

Rationality-informed protein evolution enables enhancement of PET hydrolase activity.

Journal of hazardous materials - 1 Feb 2026

Lin Wei, Zhang Jiaxing, Zhou Yu, Wang Mengfan, You Shengping, Su Rongxin, Qi Wei

Abstract excerpt

Polyethylene terephthalate (PET) waste has led to severe environmental challenges. Although enzymatic degradation of PET offers advantages such as mild reaction conditions with lower energy and reduced secondary pollution compared with conventional chemical processes, it was limited by the intrinsic insufficient catalytic activity of PET hydrolases. Recently, an active-learning method EVOLVEpro has efficiently...

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PMID: 41538944
DOI: 10.1016/j.jhazmat.2026.141130

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