Article
Central Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study.
JMIR research protocols - 15 Jan 2026
De Lott Lindsey B, Harte Steven E, Kaplan Chelsea, Williams David A, Shtein Roni, Woodward Maria A, Tsodikov Alexander, Deveney Tatiana, Galor Anat, Shea Anne, Schultz Charles, McKolay Clare, Scott Kathy A, Clauw Daniel J
Abstract excerpt
BACKGROUND: Chronic ocular surface pain (COSP), occurring either in isolation or as part of numerous ocular conditions, such as dry eye syndrome, is a leading cause of eye care visits in the United States. Conventional treatments directed at the ocular surface-the perceived pain source-are often inadequate for pain relief. We hypothesize that some individuals with COSP are experiencing symptoms driven by central...
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