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Article

PacBio long-read amplicon sequencing of dog leukocyte antigen genes at full-length level in beagle dogs.

Experimental animals - 22 Apr 2026

Konno Hiroya, Miyamae Jiro, Kajitani Rei, Kugou Kazuto, Kataoka Hiroko, Akai Makoto, Ishizaka Tomomichi, Chiba Katsuyoshi

Abstract excerpt

The major histocompatibility complex (MHC) plays a critical role in individual immune responses and susceptibility to various conditions, including autoimmune diseases and drug reactions. In dogs, the canine MHC (dog leukocyte antigen, DLA) polymorphism is key to understanding immune mechanisms, but technical challenges have impeded its comprehensive genetic analysis. This study addressed these issues by using a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class I

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Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 41535056
DOI: 10.1538/expanim.25-0111
PMCID: PMC13100700

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