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Article

Prevalence of BRCA1 and BRCA2 Variants in an Unselected Population of Women With Breast Cancer.

JAMA network open - 2 Sept 2025

Mortimer Joanne E, Lindsey Sidney S, Zukin Elyssa, Park Wai, Sturgeon Duveen, Solomon Ilana, Blazer Kathleen, Gray Stacy W, Bonner Joseph D, Gruber Stephen B

Abstract excerpt

Importance: Barriers to germline testing make it difficult to determine the prevalence of pathogenic or likely pathogenic (P/LP) variants in BRCA1 and BRCA2 in underrepresented populations. Objective: To determine P/LP variants in BRCA1 and BRCA2 in women with breast cancer enrolled in the Implementing Next-Generation Sequencing for Precision Intervention and Risk Evaluation (INSPIRE) study. Design, Setting, and...

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Source

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Identifiers

PMID: 40952741
DOI: 10.1001/jamanetworkopen.2025.31577
PMCID: PMC12439053

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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