Article
Compressive pangenomics using mutation-annotated networks.
Nature genetics - 1 Feb 2026
Walia Sumit, Motwani Harsh, Tseng Yu-Hsiang, Smith Kyle, Corbett-Detig Russell, Turakhia Yatish
Abstract excerpt
Pangenomics is an emerging field that uses collections of genomes, rather than a single reference, to reduce bias and capture intra-species diversity. However, existing pangenomic data formats face challenges in scaling to millions of genomes and primarily emphasize variation, often neglecting the underlying mutational events and evolutionary relationships. This work introduces Pangenome Mutation-Annotated...
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