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Article

FhuA-SbmA-driven resistance pathway to microcin Y triggers transcriptomic reprogramming and virulence enhancement in Salmonella Typhimurium.

International journal of biological macromolecules - 1 Jan 2026

Li Yu, Zhang Jinyu, Han Yu, Zeng Zhiwei, Chen Qinxi, Ke Wei, Cao Weisheng

Abstract excerpt

Salmonella Typhimurium poses critical safety risks owing to its multidrug resistance and persistence in food matrices. To address this threat, we focused on microcin Y (MccY) a lasso peptide with potent activity against multidrug-resistant S. typhimurium and elucidated how mutations in the FhuA/SbmA receptors mediate MccY resistance and differentially affect bacterial virulence. Molecular docking revealed that...

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Identifiers

PMID: 41519334
DOI: 10.1016/j.ijbiomac.2026.150111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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