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Article

Chromophobe thyroid carcinoma: a distinct entity associated with TSC gene alterations.

Virchows Archiv : an international journal of pathology - 1 Apr 2026

Harahap Agnes S, Pusztaszeri Marc P, Rammal Rayan, Foulkes William D, Nikiforov Yuri E, Wasserman Jason K, Seethala Raja R

Abstract excerpt

Chromophobe thyroid carcinoma (CTC) is a rare thyroid carcinoma with distinct morphology, often occurring in patients with tuberous sclerosis complex (TSC). The molecular drivers remain poorly understood. We report two additional CTC cases and review the literature including genetic query. Patient 1, an 11-year-old boy, had a 10.3-cm bilateral thyroid mass with tumoral capsular and vascular invasion....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41518426
DOI: 10.1007/s00428-025-04380-3
PMCID: PMC13053357

Genes

TSC2
BRAF
TSC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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