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Article

IbinA and IbinB regulate the Toll pathway-mediated immune response in Drosophila melanogaster.

BMC biology - 9 Jan 2026

Maasdorp Matthew K, Valanne Susanna, Vesala Laura, Vornanen Petra, Haukkavaara Elina, Tuomela Tea, Malin Aino, Salminen Tiina S, Hultmark Dan, Rämet Mika

Abstract excerpt

BACKGROUND: To combat infection, an immune system needs to be promptly activated but tightly controlled to avoid destruction of host tissues. IbinA and IbinB are related short peptides with robust expression upon microbial challenge in Drosophila melanogaster. RESULTS: Ibin genes are ubiquitously present in flies of the Drosophila subgenus Sophophora, replacing the likely evolutionarily older, related gene,...

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Identifiers

PMID: 41514329
DOI: 10.1186/s12915-025-02501-7
PMCID: PMC12882233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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