The Suggestive Association Between the NOG rs227731 Polymorphism and Non-Syndromic Cleft Lip With or Without Palate Subtypes in a Japanese Cohort.

doi:10.1002/cga.70036

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The Suggestive Association Between the NOG rs227731 Polymorphism and Non-Syndromic Cleft Lip With or Without Palate Subtypes in a Japanese Cohort.

Congenital anomalies - 1 Jan 2026

Anh Le Kha, Thao Tran Phuong, Niimi Teruyuki, Suzuki Satoshi, Hayakawa Toko, Kitagawa Ken, Sakuma Chisato, Imura Hideto, Kondo Hisataka, Tu Nguyen Huu, Son Tong Minh, Ngoc Vo Truong Nhu, Loc Pham Nguyen Gia, Furukawa Hiroo, Natsume Nagana, Natsume Nagato

Abstract excerpt

Non-syndromic cleft lip with or without palate (NSCL/P) ranks among the most prevalent congenital craniofacial anomalies globally. In Japan, reported rates of cleft lip and/or palate range from 1 in 500 to 1 in 700 live births. This study aims to explore potential sex-specific interactions of NOG rs227731 across NSCL/P subtypes in a Japanese population. This case-control study included 420 participants recruited...

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PMID: 41496661
DOI: 10.1002/cga.70036
PMCID: PMC13422759

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