Article
Rare ABCA7 mutations in Alzheimer's disease and cerebral amyloid angiopathy pathology.
Neurobiology of aging - 1 Apr 2026
Hendrickx Van de Craen Elisabeth, Bossaerts Liene, Sieben Anne, Van den Bossche Tobi, Bjerke Maria, Hanseeuw Bernard, Bergmans Bruno, Vandenberghe Rik, De Deyn Peter P, Cras Patrick, Sleegers Kristel, Engelborghs Sebastiaan, Van Broeckhoven Christine, van der Zee Julie
Abstract excerpt
Rare mutations in the ATP binding cassette subfamily A member 7 (ABCA7) gene are known risk factors for Alzheimer's disease (AD). Genetic sequencing in 1372 Belgian patients previously revealed rare ABCA7 mutations in 102 carriers, 58 with a premature termination codon mutation (PTC) and 44 with a missense mutation. Among carriers, 14 received post-mortem examination. Here, we reviewed and report the...
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