Acute Myocarditis During a Generalized Pustular Psoriasis Flare: A Possible Pharmacogenetic Interaction in the Setting of Severe Systemic Inflammation?

Abstract excerpt

We report a case of acute myocarditis in a 25-year-old man with refractory generalized pustular psoriasis (GPP) following treatment with spesolimab, an anti-IL-36 receptor monoclonal antibody. Cardiac magnetic resonance fulfilled the Lake-Louise criteria for myocarditis, and genetic testing revealed a heterozygous pathogenic/likely pathogenic MYH7 variant, suggesting a possible gene-environment-drug interaction....

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