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Article

Unraveling the Structural Basis for Antibody Synergy against Escape-Resistant Nipah Virus Mutant.

Journal of chemical information and modeling - 12 Jan 2026

Liu Jinxin, Xu Xiaole, Zhang Enhao, Luo Song, Zhang John Zenghui, Duan Lili

Abstract excerpt

Effective countermeasures are urgently needed to mitigate the potential pandemic threat posed by the highly pathogenic Nipah virus, which is capable of person-to-person transmission. This study evaluates the efficacy of three antibodies (m102.4, 1E5, and n425) against the V507I mutant strains and explores the synergistic mechanism between n425 and m102.4 using molecular dynamics simulations. Our results indicate...

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PMID: 41468569
DOI: 10.1021/acs.jcim.5c02373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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