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Article

PhenoAge and PhenoAgeAccel do not outperform chronological age in predicting physical performance decline or mortality in community-dwelling older adults.

The journals of gerontology. Series A, Biological sciences and medical sciences - 5 Feb 2026

Iuorio Maria Serena, De Vincentis Antonio, Lelli Diana, Bandinelli Stefania, Ferrucci Luigi, Antonelli Incalzi Raffaele, Pedone Claudio

Abstract excerpt

BACKGROUND: Chronological age inadequately captures interindividual variability in aging-related functional decline. Biological age metrics such as PhenoAge and PhenoAgeAccel, based on clinical biomarkers, have shown associations with frailty and mortality in clinical populations, but their utility in predicting physical performance decline in community-dwelling older adults remains uncertain. METHODS: We used...

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PMID: 41454958
DOI: 10.1093/gerona/glaf285
PMCID: PMC13376656

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