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Genetics of Chronic Shoulder Pain/Disability in South African Breast Cancer Survivors: Polygenic Contributions by Opioid and Pain Signaling Pathways.

Omics : a journal of integrative biology - 1 Jan 2026

Firfirey Firzana, Shamley Delva, September Alison V

Abstract excerpt

Chronic shoulder pain/disability is a significant cause of morbidity among breast cancer survivors, which can persist for several years postsurgery, thus markedly impacting their quality of life. The condition is a multifactorial and polygenic trait. In this overarching context, we report here on the polygenic effects through polymorphisms in opioid signaling and pain pathways, specifically, the (1) ATP-binding...

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Analgesics, Opioid
ATP Binding Cassette Transporter, Subfamily B
Cancer Survivors
Catechol O-Methyltransferase
Chronic Pain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quality of Life

Receptors, Opioid, mu

Source

Identifiers

PMID: 41449537
DOI: 10.1177/15578100251408285

Genes

ABCB1
COMT
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Genetics of Chronic Shoulder Pain/Disability in South African Breast Cancer Survivors: Polygenic Contributions by Opioid and Pain Signaling Pathways.PMID 41449537Read ↗

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