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Article

A recurrent adaptive mutation in the transmembrane 2B protein of an insect picorna-like virus in a nonnative host.

Journal of virology - 20 Jan 2026

Lezcano Oscar M, Fuhrmann Lara, Bos Reinder T, Wang Haitao, Stevens Milou, Beerenwinkel Niko, Huynen Martijn A, van Rij Ronald P

Abstract excerpt

Virus emergence is often due to cross-species transmission and adaptation to the new host. We studied the effect of innate immune responses on shaping virus populations in native and nonnative virus-host combinations, using as a model system Drosophila melanogaster infected with either Drosophila C virus (DCV) or cricket paralysis virus (CrPV). In this host, the cGAS-like receptor 1 senses viral double-stranded...

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Identifiers

PMID: 41427710
DOI: 10.1128/jvi.01239-25
PMCID: PMC12817933

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