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Article

Further evidence that painful and painless restless legs syndrome are contrasting phenotypes: a study of adult twins and their families.

Sleep medicine - 1 Feb 2026

Karroum Elias G, Bui Minh, Aouad Phillip, Ng Georgia, Teng Arthur, Walters Arthur S, Jaaniste Tiina, Hopper John, Champion G David

Abstract excerpt

OBJECTIVE: We aimed to test in adults that painful and painless phenotypes of the restless legs syndrome (RLS) differed in genetic influence and associations with comorbidities. METHODS: Twins Research Australia administered questionnaires to adult twins and their families. Responders self-reported RLS (Cambridge-Hopkins diagnostic questionnaire) and painful and painless subsets, their history of doctor-confirmed...

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Identifiers

PMID: 41389619
DOI: 10.1016/j.sleep.2025.108718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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