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Article

Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY.

Redox biology - 1 Apr 2021

Wang Xiaojing, Lam Sin Man, Cao Mingjun, Wang Tong, Wang Zhixin, Yu Miao, Li Bowen, Zhang Huabing, Ping Fan, Song Guangyao, Feng Kai, Zhang Qian, Xu Jianping, Zhou Liyuan, Deng Mingqun, Zhai Xiao, Xiao Xinhua, Shui Guanghou

Abstract excerpt

Glucokinase-maturity onset diabetes of the young (GCK-MODY) represents a rare genetic disorder due to mutation in the glucokinase (GCK) gene. The low incidence of vascular complications in GCK-MODY makes it a natural paradigm for interrogating molecular mechanisms promoting vascular health under prolonged hyperglycemia. Clinical rate of misdiagnosis has remained high, and a reliable serum lipid biomarker that...

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Identifiers

PMID: 33450726
DOI: 10.1016/j.redox.2021.101855
PMCID: PMC7810764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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