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Article

New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein.

BMC cancer - 10 Dec 2025

Hong Yaonan, Wang Xu, Dong Jingjie, Liu Qi, Shen Yingying, Yang Xiawan, Wang Peicheng, Li Wenjie, Ye Baodong, Shao Keding, Kuo Ya-Huei, Wu Dijiong

Abstract excerpt

OBJECTIVE: Acute myeloid leukemia (AML) is a malignant blood disease with a poor prognosis. With the development of targeted therapies, many refractory/relapsed or unfit AML patients have achieved better survival rates. However, primary or acquired resistance frequently occurs, and some targets become unavailable. This study aimed to identify and verify novel targets for AML using Mendelian Randomization (MR)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41372872
DOI: 10.1186/s12885-025-15438-5
PMCID: PMC12822165

Genes

TCL1A

Provenance

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