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Article

Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease.

Journal of the American Heart Association - 16 Dec 2025

Sheng Chang, Zhou Rui, Wang Hongcai, Ling Jin, Lin Guoqiang, Yang Pu, Wang Wei

Abstract excerpt

BACKGROUND: Estimated pulse wave velocity (ePWV), a noninvasive marker of arterial stiffness, reflects vascular aging and has been associated with increased coronary artery disease (CAD) risk. However, the interplay between ePWV and genetic factors, including polygenic risk score (PRS) and apolipoprotein E genotypes, in determining CAD susceptibility remains unclear. METHODS: We analyzed data from the HRS (Health...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Middle Aged
Aging
Apolipoproteins E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Black or African American

Coronary Artery Disease

Genetic Predisposition to Disease

Incidence

Pulse Wave Analysis

Risk Assessment

Risk Factors

United States

Vascular Stiffness

White

Source

Open in PubMed Open full text

Identifiers

PMID: 41368830
DOI: 10.1161/JAHA.125.042610
PMCID: PMC12826937

Genes

CAD

Provenance

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