The utility of angiopoietin-2 and blood cell-derived biomarker indices in differentiating rapidly improving acute respiratory distress syndrome (RIARDS) phenotype from persistent-ARDS: a prospective observational study.

doi:10.1080/07853890.2025.2596535

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Article

The utility of angiopoietin-2 and blood cell-derived biomarker indices in differentiating rapidly improving acute respiratory distress syndrome (RIARDS) phenotype from persistent-ARDS: a prospective observational study.

Annals of medicine - 1 Dec 2025

Srinivas Thejesh, R Bhat Vinutha, R Shwethapriya, Todur Pratibha, Hanumaiah Gagana, Ravindra Prithvishree, Nagendra Danavath, U Kamath Shobha, A Udupa Ashritha, Rao Shruthi, Chaudhuri Souvik

Abstract excerpt

BACKGROUND: Rapidly improving acute respiratory distress syndrome (RIARDS) is defined as normalization of oxygenation (PaO2/FiO2 >300 mmHg) within 24 h of invasive mechanical ventilation. Angiopoietin-2 (Ang-2), a marker of endothelial dysfunction, may predict acute respiratory distress syndrome (ARDS) outcomes, but its role in RIARDS is unclear. This study evaluated Ang-2 and other biomarkers for predicting...

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Topics

Humans
Angiopoietin-2
Respiratory Distress Syndrome
Female
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Biomarkers

Prospective Studies

Aged

Respiration, Artificial

Phenotype

Prognosis

Adult

Intensive Care Units

Diagnosis, Differential

Source

Open in PubMed Open full text

Identifiers

PMID: 41360733
DOI: 10.1080/07853890.2025.2596535
PMCID: PMC12687898

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