Article
Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group.
Cancer - 1 May 2018
Teot Lisa A, Schneider Michaela, Thorner Aaron R, Tian Jing, Chi Yueh-Yun, Ducar Matthew, Lin Ling, Wlodarski Marcin, Grier Holcombe E, Fletcher Christopher D M, van Hummelen Paul, Skapek Stephen X, Hawkins Douglas S, Wagers Amy J, Rodriguez-Galindo Carlos, Hettmer Simone
Abstract excerpt
BACKGROUND: Pediatric paired box 3:forkhead box protein O1 fusion-negative (PF-) rhabdomyosarcoma (RMS) represents a diverse spectrum of tumors with marked differences in histology, myogenic differentiation, and clinical behavior. METHODS: This study sought to evaluate the clinical and mutational spectrum of 24 pediatric PF- human RMS tumors with high levels of myogenic differentiation. Tumors were sequenced with...
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