Genetic background influences the extent and severity of cilia-related congenital anomalies in Ift56/Ttc26 mutant mice.

Abstract excerpt

Multiple congenital anomalies have been linked to defects in the formation or function of a small cellular organelle called the cilium. The severity of cilia-related syndromes (ciliopathies) ranges from viable with fertility defects to embryonic lethal, often with different mutations in the same gene resulting in highly variable phenotypes. While some of the disparity is likely due to differential effects of...

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