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Article

Brain imaging signature of neuropathic pain phenotypes in small-fiber neuropathy: altered thalamic connectome and its associations with skin nerve degeneration.

Pain - 1 May 2021

Chao Chi-Chao, Tseng Ming-Tsung, Lin Yea-Huey, Hsieh Paul-Chen, Lin Chien-Ho Janice, Huang Shin-Leh, Hsieh Sung-Tsang, Chiang Ming-Chang

Abstract excerpt

ABSTRACT: Small-fiber neuropathy (SFN) has been traditionally considered as a pure disorder of the peripheral nervous system, characterized by neuropathic pain and degeneration of small-diameter nerve fibers in the skin. Previous functional magnetic resonance imaging studies revealed abnormal activations of pain networks, but the structural basis underlying such maladaptive functional alterations remains elusive....

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Identifiers

PMID: 33239524
DOI: 10.1097/j.pain.0000000000002155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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