Article
Genome-wide screening for cis-regulatory variation using a classical diallel crossing scheme.
Nucleic acids research - 1 Jan 2006
Kiekens Raphaël, Vercauteren Annelies, Moerkerke Beatrijs, Goetghebeur Els, Van Den Daele Hilde, Sterken Roel, Kuiper Martin, van Eeuwijk Fred, Vuylsteke Marnik
Abstract excerpt
Large-scale screening studies carried out to date for genetic variants that affect gene regulation are generally limited to descriptions of differences in allele-specific expression (ASE) detected in vivo. Allele-specific differences in gene expression provide evidence for a model whereby cis-acting genetic variation results in differential expression between alleles. Such gene surveys for regulatory variation...
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