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Article

Longitudinal characterization of impulsivity phenotypes boosts signal for genomic correlates and heritability.

Molecular psychiatry - 1 Feb 2025

Deng Wei Q, Belisario Kyla, Munafò Marcus R, MacKillop James

Abstract excerpt

Genomic correlates of impulsivity have been identified in several genome-wide association studies (GWAS) using cross-sectional designs, but no studies have investigated the molecular genetic correlates of impulsivity phenotypes using longitudinally constructed traits. In 3860 unrelated European participants in the Avon Longitudinal Study of Parents and Children (ALSPAC), we constructed longitudinal phenotypes for...

Read the complete abstract on PubMed

Topics

Humans
Impulsive Behavior
Phenotype
Male
Genome-Wide Association Study
Female
Longitudinal Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Polymorphism, Single Nucleotide

Delay Discounting

Cross-Sectional Studies

Multifactorial Inheritance

Genetic Predisposition to Disease

Personality

Young Adult

Genomics

Source

Identifiers

PMID: 39181994
DOI: 10.1038/s41380-024-02704-4

Genes

CADM2
NCAM1

Provenance

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