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Article

The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jun 2016

Wallace Daniel F, Subramaniam V Nathan

Abstract excerpt

PURPOSE: The prevalence of HFE-related hereditary hemochromatosis (HH) among European populations has been well studied. There are no prevalence data for atypical forms of HH caused by mutations in HFE2, HAMP, TFR2, or SLC40A1. The purpose of this study was to estimate the population prevalence of these non-HFE forms of HH. METHODS: A list of HH pathogenic variants in publically available next-generation sequence...

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Source

Identifiers

PMID: 26633544
DOI: 10.1038/gim.2015.140

Genes

HFE
HAMP
TFR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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