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Article

Endometriosis - on the intersection of modern environmental pollutants and ancient genetic regulatory variants.

European journal of human genetics : EJHG - 1 Feb 2026

Warren Amelia, Andreou Demetra, Warren Dean, Wieland Jack, Mantzouratou Anna

Abstract excerpt

Endometriosis is a chronic, estrogen-driven inflammatory disorder affecting approximately 10% of reproductive-aged women globally. Despite increasing genomic insights into advanced-stage disease, the genetic underpinnings of early-stage endometriosis remain poorly understood, limiting opportunities for timely diagnosis and intervention. This study explores the contribution of regulatory variants, including those...

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Source

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Identifiers

PMID: 41266756
DOI: 10.1038/s41431-025-01977-9
PMCID: PMC12858970

Genes

CNR1
IDO1
KISS1R
TACR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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