The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome.

doi:10.3389/fendo.2025.1644373

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The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome.

Frontiers in endocrinology - 1 Jan 2025

Wang Qiuyi, Liang Jiagui, Liu Qingqing, Liu Hongwei, Bai Huai, Huang Wei, Fan Ping

Abstract excerpt

Background: Oxidative stress and metabolic disorders significantly contribute to the development of polycystic ovarian syndrome (PCOS). Heme oxygenase-1 (HMOX1) plays a key role in the degradation of heme and the regulation of oxidative stress, ferroptosis, and glycolipid metabolism. This study explored the relationship between HMOX1 promoter T-413A single nucleotide polymorphism (SNP, rs2071746), (GT)n...

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Identifiers

PMID: 41262262
DOI: 10.3389/fendo.2025.1644373
PMCID: PMC12623185

Genes

HMOX1

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