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Heme oxygenase 2 genetic variants alter hormonal and metabolic traits in polycystic ovary syndrome

22 Jan 2024

Abstract excerpt

Oxidative stress and metabolic disorders are involved in the pathogenesis of polycystic ovary syndrome (PCOS). Heme oxygenase 2 (HMOX2) plays a critical role in preserving heme metabolism as well as in modulating glycolipid metabolism, oxidative stress, and inflammation. This study examined the correlation between HMOX2 G554A (rs1051308) and A-42G (rs2270363) genetic variants with the risk of PCOS and assessed...

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PMID: 38251965
DOI: 10.1530/ec-23-0463

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