Association of vitamin D receptor gene polymorphisms ApaI (rs7975232) and BsmI (rs1544410) with hepatocellular carcinoma susceptibility in Egyptian patients.

doi:10.1007/s11033-025-11140-8

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Association of vitamin D receptor gene polymorphisms ApaI (rs7975232) and BsmI (rs1544410) with hepatocellular carcinoma susceptibility in Egyptian patients.

Molecular biology reports - 19 Nov 2025

Alrdahe Salma Saleh, Albalawi Aishah E, Darwish Doaa Bahaa Eldin, Omran Awatif M E, Almasaudi Nada Mohammed, Elsaid Afaf M, Youssef Magdy M

Abstract excerpt

BACKGROUND: Globally, hepatocellular carcinoma (HCC) is a widespread cancer, with a rising incidence rate. Polymorphisms in the vitamin D receptor (VDR) gene were found to be related to the emergence of tumors in various organs. AIM: This study aimed to examine the association of the polymorphic VDR gene with HCC development in Egyptian patients. METHODS: Gene polymorphism analyses for VDR ApaI (rs7975232 A > C)...

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PMID: 41258623
DOI: 10.1007/s11033-025-11140-8

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