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Article

Young-onset hepatocellular carcinoma following double outlet right ventricle surgery without liver congestion: a case report with genetic analysis.

Clinical journal of gastroenterology - 1 Feb 2026

Osawa Yosuke, Akita Takayuki, Hata Taigo, Aida Takashi, Ohtake Takaaki

Abstract excerpt

AIM: Congenital heart disease (CHD) can lead to liver dysfunction and HCC, typically through congestion, hypoxia, or low cardiac output. However, HCC development without these factors is not well understood. METHODS: We report a 16-year-old girl with a history of double outlet right ventricle surgery in infancy, without Fontan procedure. Imaging and histology confirmed HCC without liver fibrosis, inflammation, or...

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Identifiers

PMID: 41251886
DOI: 10.1007/s12328-025-02248-2

Genes

HNF1A
MAP3K1
MUC16
PABPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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