Article
Genomic and transcriptomic profiling of hepatocellular carcinoma in patients with Fontan-associated liver disease.
Hepatology (Baltimore, Md.) - 1 Aug 2026
Yamazoe Taiji, Kakazu Eiji, Matsuda Michitaka, Mino Masaaki, Mori Taizo, Yoshio Sachiyo, Tsutsui Yuriko, Motomura Takashi, Itoh Shinji, Haruki Koichiro, Furukawa Kenei, Yamada Shinichiro, Takamoto Takeshi, Noda Takehiro, Eguchi Hidetoshi, Hasegawa Kiyoshi, Morine Yuji, Ikegami Toru, Yoshizumi Tomoharu, Kanto Tatsuya
Abstract excerpt
BACKGROUND AND AIMS: Fontan-associated liver disease (FALD) could lead to liver cirrhosis and hepatocellular carcinoma (HCC). The prognosis of FALD patients is worse when HCC develops. Therefore, a better understanding of the mechanisms of FALD hepatocarcinogenesis is critical. We investigated the genomic and transcriptomic signatures of FALD HCC. APPROACH AND RESULTS: Ten patients with FALD HCCs, 2 patients with...
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