Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study.

doi:10.1016/j.jagp.2025.10.005

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Article

Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Aug 2026

Leffa Douglas Teixeira, Zhang Yingjin, Wang Yueting, Teverovsky Esther G, Jacobsen Erin, Bellaver Bruna, Ferreira Pamela C L, Fan Kang-Hsien, Kamboh M Ilyas, Karikari Thomas K, Chang Chung-Chou H, Snitz Beth E, Molina Brooke S G, Pascoal Tharick A, Ganguli Mary

Abstract excerpt

OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) has been associated with increased risk for dementia, including Alzheimer's disease (AD). Polygenic risk scores for ADHD (ADHD-PRS) reflect the genetic liability for the disorder and have been linked to cognitive decline in selected clinical samples. This study examined associations between ADHD-PRS and cognitive function in older adults from a...

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PMID: 41241612
DOI: 10.1016/j.jagp.2025.10.005
PMCID: PMC12817166

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