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Article

VEGFA-centric angiogenic genetic variants drive hypertension and dyslipidaemia susceptibility in type 2 diabetes mellitus: A multilocus synergistic cohort study.

Diabetic medicine : a journal of the British Diabetic Association - 1 Feb 2026

Zuo Chao, Chen Hailian, Lu Xiang, Cheng Jing, Yang Dongli, Liu Yi, Guo Mengna, Yang Zhuo, Wang Ziqiang, Wang Yu, Qiao Yongchao

Abstract excerpt

BACKGROUND: The interplay between angiogenic genetic variants and metabolic-vascular comorbidities in type 2 diabetes mellitus (T2DM) remains poorly elucidated. This cohort study investigated the synergistic effects of VEGFA-centric polymorphisms on hypertension (HTN) and dyslipidaemia (DYS) susceptibility in T2DM. METHODS: We enrolled 440 individuals stratified into three groups: T2DM-only (n = 258), T2DM+HTN...

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Share to Angiopoietin-2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

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Share to Receptor, Angiotensin, Type 1

Share to Transforming Growth Factor beta1

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 41225145
DOI: 10.1111/dme.70169

Genes

VEGFA
AGTR1
ANGPT2
CRP
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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