An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder.

doi:10.1038/srep22851

Article

An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder.

Scientific reports - 7 Mar 2016

Lima Leandro de Araújo, Feio-dos-Santos Ana Cecília, Belangero Sintia Iole, Gadelha Ary, Bressan Rodrigo Affonseca, Salum Giovanni Abrahão, Pan Pedro Mario, Moriyama Tais Silveira, Graeff-Martins Ana Soledade, Tamanaha Ana Carina, Alvarenga Pedro, Krieger Fernanda Valle, Fleitlich-Bilyk Bacy, Jackowski Andrea Parolin, Brietzke Elisa, Sato João Ricardo, Polanczyk Guilherme Vanoni, Mari Jair de Jesus, Manfro Gisele Gus, do Rosário Maria Conceição, Miguel Eurípedes Constantino, Puga Renato David, Tahira Ana Carolina, Souza Viviane Neri, Chile Thais, Gouveia Gisele Rodrigues, Simões Sérgio Nery, Chang Xiao, Pellegrino Renata, Tian Lifeng, Glessner Joseph T, Hashimoto Ronaldo Fumio, Rohde Luis Augusto, Sleiman Patrick M A, Hakonarson Hakon, Brentani Helena

Abstract excerpt

Many studies have attempted to investigate the genetic susceptibility of Attention-Deficit/Hyperactivity Disorder (ADHD), but without much success. The present study aimed to analyze both single-nucleotide and copy-number variants contributing to the genetic architecture of ADHD. We generated exome data from 30 Brazilian trios with sporadic ADHD. We also analyzed a Brazilian sample of 503 children/adolescent...

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An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder.

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