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Article

Establishment of a Padlock Probe-Based Fluorescence Quantitative PCR Method for the Detection of the SARS-CoV-2 Omicron S371L Mutation.

Journal of fluorescence - 1 Feb 2026

Zhong Yangqing, Yu Luxin, Lin Yanzhen, Xu Wenjuan, Chen Lingwei, Chen Zhangquan, Xiao Xiang

Abstract excerpt

This study aimed to establish and validate a novel detection method that combines padlock probe technology with fluorescence quantitative PCR (qPCR) for the rapid and specific detection of the SARS-CoV-2 Omicron S371L mutation in the spike protein. Padlock probes and amplification primers were designed and synthesized based on the Omicron S371L mutation site. The probe was designed to anneal with high specificity...

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PMID: 41205020
DOI: 10.1007/s10895-025-04624-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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