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Article

Mendelian randomization analysis of gut microbiota and chronic kidney disease: Implications for herbal interventions.

Medicine - 7 Nov 2025

Hu Xulei, Wang Le, Lin Chen, Zhu Zhengyang, Yang Shuqin, Wang Sicun, Wang Yiping, Jin Hua, Lv Yong, Wang Dong, Zhang Xuelian, Ren Kejun

Abstract excerpt

Based on the gut-kidney axis theory and using Mendelian randomization (MR), this study investigated the potential causal relationship between gut microbiota and chronic kidney disease (CKD), and explored candidate Chinese herbal medicines (CHM) that may treat gut microbiota for CKD management. Genome-wide association study summary statistics of gut microbiota and CKD were obtained from the NHGRI-EBI genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Renal Insufficiency, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 41204553
DOI: 10.1097/MD.0000000000045730
PMCID: PMC12599771

Genes

CHM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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