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Article

Analysis of the causal association between systemic lupus erythematosus and osteonecrosis: A bidirectional 2-sample Mendelian randomization study.

Medicine - 7 Nov 2025

Zhang Leilei, Zhu Xuanye, Ling Haonan, Duan Ruimeng, Zhang Ying, Zhu Yingjie, Liu Youwen, Chen Xiantao

Abstract excerpt

Previous studies have indicated that multisite osteonecrosis (ON), particularly femoral head necrosis, is a common and serious complication of systemic lupus erythematosus (SLE). However, the pathogenesis of ON in patients with SLE is unclear and existence of a causal relationship between SLE and ON remains uncertain. Therefore, using summary-level data from large-scale genome-wide association studies of European...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41204486
DOI: 10.1097/MD.0000000000045457
PMCID: PMC12599635

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