Article
Multi-ancestry genome-wide association analyses of polycystic ovary syndrome.
Nature genetics - 1 Nov 2025
Zhao Han, Xu Yuping, Xue Baiqiang, Zhao Shigang, Zhang Manfei, Wu Xiao-Ke, Wang Tianjuan, Wen Yanqin, Li Shumin, Zhang Qing, Yang Ziyi, Sun Hui, Pan Ting, Lian Yihong, Gao Xueying, Gao Chengwen, Wang Zhao, Wu Chuanhong, Zhang Changming, Jian Xuemin, Peng Lixia, Zhang Xin, Wang Baokun, Wei Lieqing, He Yuyan, Xia Disong, Wu Ziyun, Yang Qiangzhen, Sun Yuanchao, Ding Yonghe, Du Siyuan, Xia Guofeng, Jing Yulong, Xu Hairong, Shi Weiye, Liu Junting, He Lin, Chen Zi-Jiang, Cao Yunxia, Li Zhiqiang, Shi Yongyong
Abstract excerpt
Polycystic ovary syndrome (PCOS), the leading endocrine disorder in women of reproductive age, is highly heritable, yet its polygenic architecture remains poorly understood. Here we conducted a genome-wide association study on 12,419 Chinese women with PCOS and 34,235 controls, followed by a multi-ancestry meta-analysis with up to 13,773 European cases and 411,088 controls, identifying 94 independent loci, 73 of...
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