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Article

Synergism between obesity and HFpEF on neutrophils phenotype and its regulation by adipose tissue-molecules and SGLT2i dapagliflozin.

Journal of cellular and molecular medicine - 1 Aug 2022

Almengló Cristina, Fu Xiaoran, Flores-Arias María Teresa, Fernández Ángel L, Viñuela Juan E, Martínez-Cereijo José M, Durán Darío, Rodríguez-Mañero Moisés, González-Juanatey José R, Eiras Sonia

Abstract excerpt

The adiposity invokes innate immune activity, coronary microvascular dysfunction and consequently heart failure preserved ejection fraction (HFpEF). Our aim was to study the neutrophils profile on obesity and cardiovascular disease and its regulation by adipose tissue-secretome and dapagliflozin. We have isolated neutrophils from patients undergoing open heart surgery (19 women and 51 men). Its migration activity...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35818731
DOI: 10.1111/jcmm.17466
PMCID: PMC9357605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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