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Article

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors.

Journal of visualized experiments : JoVE - 17 Oct 2025

Ge Jiani, Sun Yunfan, Hua Jingsheng, Huang Yuanhong, Wang Yi, Tang Dandan, Wang Taoyun, Li Jinli, Deng Yanfeng, Liu Song-Bai

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3), a class III receptor tyrosine kinase, exhibits a mutation frequency of approximately 30% in acute myeloid leukemia (AML) patients and constitutes a critical therapeutic target. As representative type I and type II FLT3 inhibitors, respectively, gilteritinib and Quizartinib (AC220) are clinically employed in FLT3-mutant AML management. Gilteritinib inhibits both activated and...

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Identifiers

PMID: 41182989
DOI: 10.3791/68469

Genes

FLT3
AXL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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