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Preoperative molecular classification of endometrial cancer: Validation through biopsy and matched hysterectomy specimens.

Gynecologic oncology - 1 Dec 2025

Nozaki Takahiro, Sakamoto Ikuko, Kagami Keiko, Matsuda Kosuke, Uchida Mitsunori, Kouchi Yusuke, Amemiya Kenji, Hirotsu Yosuke, Tajiri Ryosuke, Oyama Toshio, Omata Masao

Abstract excerpt

OBJECTIVE: To evaluate the concordance of molecular classification between preoperative endometrial biopsy and corresponding hysterectomy specimens in endometrial cancer, and to assess the feasibility of using biopsy specimens for genomic profiling and recurrence risk stratification. METHODS: We retrospectively analyzed 116 patients with endometrial carcinoma or uterine carcinosarcoma treated between 2014 and...

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PMID: 41175447
DOI: 10.1016/j.ygyno.2025.10.026

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